Figure 3
Application of the Hamilton R-factor ratio test to comparison of a hybrid model containing both TLS and Biso terms to a model containing only one or the other. (a) Comparison of a pure TLS model to a hybrid TLS + Biso model for the 3 Å resolution refinement of 3hzr. The acceptance surface is only slightly larger than that shown in Fig. 2(b). (b) Comparison of a pure TLS model to a hybrid TLS + Biso model for the 2.32 Å resolution refinement of the homologous tryptophanyl-tRNA synthetase from Campylobacter jejuni (PDB entry 3m5w). In this case the R-factor ratio (yellow surface) is greater than DF(1)/DF(2) (green surface) everywhere except the bounding limit wADP = wgeom = 0. |