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Figure 3
Two examples of rare isoleucine rotamers that were unambiguously observed in good electron density in structures determined at around 1.0 Å resolution. Left: Ile337 in chain A of the triacylglycerol lipase protein (PDB entry 1d5t; Brzozowski et al., 2000BB4) is observed in section 1. Right: Ile15 in chain B of the HIV protease (PDB entry 1kzk; Reiling et al., 2002BB47) is observed in section 2. Electron densities were obtained from the EDS server and are contoured at 1.4σ. At the local structures of these residues are shown and the interactions that keep the residues in these unfavourable rotamers are explained. MolProbity (Chen et al., 2010BB9) and WHAT_CHECK (Hooft, Vriend et al., 1996BB20) call these two rotamers `poor'. We believe that `improbable' is a better description.

Journal logoSTRUCTURAL
ISSN: 2059-7983
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