 | Acta Crystallographica Section D Acta Crystallographica Section D BIOLOGICAL CRYSTALLOGRAPHY |
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![[Figure 8]](rr5077fig8mag.jpg)
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Figure 8
DEN refinement was essential to determine the structure of myxovirus resistance (MxA) protein (Gao et al., 2011  ). (a) The starting model (green) for refinement consisted of a previously determined structure of the MxA stalk domain, a homology model of the G domain and an initial model for the BSE domain, which could be manually built into the electron-density map with phases obtained by molecular replacement. The structure obtained by DEN refinement (orange) showed better defined secondary-structure geometry compared with a structure obtained by refinement without DEN restraints (magenta). The electron density obtained from the refinement without DEN restraints (b) showed wrong connectivity in many places and less well defined side chains than the electron density obtained by DEN refinement (c). |
![[Figure 8]](rr5077fig8.jpg)
| BIOLOGICAL CRYSTALLOGRAPHY |
ISSN: 1399-0047
