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Figure 7
A stereoview of a model of the aromatic substrate 2,4′-DHAP in the active site. The 2,4′-DHAP (shown in dark green) occupies the positions of the putative glycerol and carbonate. The phenolic –OH group interacts with Asp63 and Trp61 by hydrogen bonds and the α-­hydroxyketone group of 2,4′-DHAP interacts with the active-site iron by dative bonding and with the side chain of Tyr93 by a hydrogen bond. Note that the side chain of Phe129 which, like Phe43, interacts with the substrate by ring stacking has been omitted from the foreground for clarity.

Journal logoBIOLOGICAL
ISSN: 1399-0047
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