Structure of the 2,4′-dihydroxyacetophenone dioxygenase from Alcaligenes sp. 4HAP

Keegan, R.; Lebedev, A.; Erskine, P.; Guo, J.; Wood, S.P.; Hopper, D.J.; Rigby, S.E.J.; Cooper, J.B.

doi:10.1107/S1399004714015053

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 7
A stereoview of a model of the aromatic substrate 2,4′-DHAP in the active site. The 2,4′-DHAP (shown in dark green) occupies the positions of the putative glycerol and carbonate. The phenolic –OH group interacts with Asp63 and Trp61 by hydrogen bonds and the α-hydroxyketone group of 2,4′-DHAP interacts with the active-site iron by dative bonding and with the side chain of Tyr93 by a hydrogen bond. Note that the side chain of Phe129 which, like Phe43, interacts with the substrate by ring stacking has been omitted from the foreground for clarity.

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 70| Part 9| August 2014| Pages 2444-2454

doi:10.1107/S1399004714015053

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