Figure 1
The overall structure of NQ-HaBLA. The asymmetric units of NQ-HaBLA from (a) condition 1B (75 mM Na+/25 mM Cs+) and (b) condition 2A (0 mM Ca2+/200 mM Sr2+) are shown. Chains A, B and C are coloured red, blue and green, respectively. The orange, magenta and cyan spheres show Ca2+, Sr2+ and Cs+, respectively. (c) Sr2+-bound and Cs+-bound structure of NQ-HaBLA, in which Sr2+ and Cs+ observed around chains A, B and C in condition 1B and condition 2A are integrated into a single molecule of NQ-HaBLA. The residues recognizing Sr2+ and Cs+ are shown as blue sticks. The active-site residues are shown as yellow sticks. |