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Figure 1
(a) Chemical structures of bisphosphonates. Nitrogen-containing bisphosphonates such as zoledronate and ibandronate have a hydroxyl group in the R1 position and nitrogen-containing R2 side chains. (b) Farnesyl pyrophosphate synthase-catalyzed condensation reactions. Isopentenyl diphosphate (IPP) first reacts with dimethylallyl diphosphate (DMAPP) to form geranyl diphosphate (GPP), releasing pyrophosphate (PPi). GPP then reacts with IPP to form farnesyl pyrophosphate (FPP) and free PPi.

Journal logoBIOLOGICAL
CRYSTALLOGRAPHY
ISSN: 1399-0047
Volume 71| Part 3| February 2015| Pages 721-731
doi:10.1107/S1399004715001121
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