Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa

Schmidberger, J.W.; Schnell, R.; Schneider, G.

doi:10.1107/S1399004715001121

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 3
Upper panel: cartoon representation of the PaFPPS homodimer with chain A coloured from blue to red from the N-terminus to the C-terminus. Chain B is shown in grey. Helices are labelled A–J. Lower panel: a 90° rotation about a horizontal axis to show the layered topology of the PaFPPS dimer. In chain B (grey) the S1 binding site for inhibitors such as ibandronate and the allosteric site are indicated by an asterisk (S1 site) and a triangle (allosteric site).

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 71| Part 3| February 2015| Pages 721-731

doi:10.1107/S1399004715001121

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