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Figure 5
Schematic model of the organization of two HMGB1 molecules with each box A bound to the same DNA-binding site, as in our structure. The binding of box A (in purple) of both proteins through the Phe37 pair kinks the DNA by about 85° (a). The binding of each box B domain (in green) can originate the formation of a loop (b) or other DNA conformation (c). For simplicity, the acidic tails have not been drawn.

Journal logoBIOLOGICAL
ISSN: 1399-0047
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