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Figure 5
Putative mechanism of protease entrapment and inhibition by ECAM. ECAM with a membrane anchor within the periplasm of bacteria encounters protease and forms a covalent complex upon cleavage, inhibiting the protease from the cleavage of large substrates. The main body of ECAM anchored to the inner membrane is shown in grey and contains the domains showing little movement (MG4, MG8 and BRD) between native and protease-activated structures or that are not present in the protease-activated structure (MG1–MG3 and MG7). The blue TED arm (TED, CUB, CTMG and MG9 domains) and green MG6 arm (MG5 and MG6 domains) entrap the protease with the blue arm containing the thioester that forms a covalent bond.

Journal logoBIOLOGICAL
CRYSTALLOGRAPHY
ISSN: 1399-0047
Volume 71| Part 7| June 2015| Pages 1478-1486
doi:10.1107/S1399004715008548
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