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![[Figure 1]](dz5371fig1mag.jpg)
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Figure 1
Examples of electron densities of fragments and histidine bound to TcHisRS. σA-weighted Fobs − Fcalc electron-density maps calculated by omitting histidine and fragments are shown in green (positive) and red (negative) contours at the 3σ level, and σA-weighted 2Fobs − Fcalc electron densities are shown in light blue at the 1.0σ level. Histidine and fragments are depicted as ball-and-stick models, while TcHisRS is shown in ribbon representation. The bound fragments shown are from structures determined from individual soaks with (a) Chem 262, (b) Chem 84, (c) Chem 166 and (d) Chem 145. For chemical formulae, see Table 2 ![[link]](../../../../../../logos/arrows/d_arr.gif) . For some fragments, such as those shown in (c) and (d), the densities can only be fully accounted for by modeling alternative binding modes of the fragment. |
![[Figure 1]](dz5371fig1.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
