Figure 7
Part of the active site of inosine 5′-monophosphate (IMP) dehydrogenase (IMPDH). (a) T. foetus IMPDH (PDB entry 1lrt; Gan et al., 2002). (b) Human IMPDH (PDB entry 1b3o; Colby et al., 1999). The correct cis-Asn303 from PDB_REDO is shown in green. The NAD+ analogue is β-methylene thiazole-4-carboxamide adenine dinucleotide (β-Me-TAD) in PDB entry 1lrt and selenazole-4-carboxamide adenine dinucleotide (SAD) in PDB entry 1b3o. The IMP analogue 6-chloropurine riboside 5′-monophosphate (6-Cl-IMP) is covalently bound to Cys331 in PDB entry 1b3o. The wires trace the Cα atoms. Water molecules have been omitted for clarity. |