Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects

Reichen, C.; Madhurantakam, C.; Hansen, S.; Grütter, M.G.; Plückthun, A.; Mittl, P.R.E.

doi:10.1107/S2059798315023116

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 4
Superposition of Y_IIIM₅A_III (third-generation C-cap; PDB entry 4plq; salmon) on Y_IIIM₅A_II (second-generation C-cap; blue). (a) Residues at the M₃–M₄ interface. General distances and hydrogen bonds are shown as grey and orange dotted lines, respectively. Distance values refer to Y_IIIM₅A_III. The superposition is based on all C^α atoms from M₃. (b) Residues at the M₅–C-cap interface. Numbers refer to positions in the repeat (Fig. 1

c), with subscripts indicating the internal repeat number or the C-cap. Side chains of all residues that differ between Y_II and Y_III and some residues from the hydrophobic core are shown in stick representation. The superposition is based on all C^α atoms from M₅.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 72| Part 1| January 2016| Pages 168-175

https://doi.org/10.1107/S2059798315023116

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