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Figure 8
Interactions of the U4 Sm-site heptad with the Sm protein-binding pockets. (a) A118 bound in SmF: O2′ of A118 is hydrogen-bonded to the OP1 atom of G125 in the background. (b) A119 bound in SmE: N7 of A119, which is methylated by DMS, is located near the axis of the π-system of Tyr53 of SmE, whereas N7 of A118, which is not methylated by DMS, is distant from the axis of the π-system of Tyr39 of SmF. (c) U120 bound in SmG. (d) U121 bound in SmD3. (e) U122 bound in SmB. (f) U123 bound in SmD1. (g) U124 bound in SmD2. See the text for details of the contact residues. |
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