view article

Figure 1
High-mannose N-glycans are added to Asn-X-Ser/Thr sequons in the endoplasmic reticulum (first two panels) and can be modified into complex-type glycans in the Golgi apparatus (third and fourth panels). Inhibitors such as kifunensine or growth in mutant mammalian cell lines (GnTI expression) limits N-linked glycan addition to high-mannose forms. Complex-type glycans are distinguished from high-mannose glycans by the addition of a core fucose at the base and negatively charged sialic acids at the tips.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Follow Acta Cryst. D
Sign up for e-alerts
Follow Acta Cryst. on Twitter
Follow us on facebook
Sign up for RSS feeds