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Figure 1
High-mannose N-glycans are added to Asn-X-Ser/Thr sequons in the endoplasmic reticulum (first two panels) and can be modified into complex-type glycans in the Golgi apparatus (third and fourth panels). Inhibitors such as kifunensine or growth in mutant mammalian cell lines (GnTI− expression) limits N-linked glycan addition to high-mannose forms. Complex-type glycans are distinguished from high-mannose glycans by the addition of a core fucose at the base and negatively charged sialic acids at the tips.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 73| Part 10| October 2017| Pages 822-828
https://doi.org/10.1107/S2059798317013353
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