Figure 1
The structurally divergent homologues (a) ecdysone phosphate phosphatase (PDB entry 3c7t) and (b) phytase (PDB entry 1qwo), coloured as a spectrum from blue (N-terminus) to red (C-terminus), share a 73-residue core, as shown in (c) and (d), respectively, containing the characteristic catalytic His and Arg residues shown as sticks. A similar 90-residue ensemble polyalanine search model derived from CONCOORD processing of 3c7t (e) could solve the structure of 1qwo and contained a structural core containing the catalytic His and Arg positions (pink sticks). |