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![[Figure 2]](di5015fig2mag.jpg)
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Figure 2
Overview of the single-homologue truncation mode of AMPLE. The distant homologue, in this case PDB entry 3c7t, is shown on the left coloured from blue (N-terminus) to red (C-terminus) with the catalytic His and Arg residues, which are conserved across the superfamily, coloured magenta, shown as sticks and labelled in the inset. A selection of truncations down to 15% of residues remaining, driven by the metrics shown, produces the search models shown in the centre. With the exception of ConSurf, the truncation produces well defined cores containing three or four catalytic residues, shown in magenta and labelled, that solve the distantly homologous targets shown on the right. |
![[Figure 2]](di5015fig2.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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