Figure 7
Diversity of MT ultrastructure in neurons. (a) A range of particle sizes and distributions are seen in the lumen of neuronal MTs. (b) The majority (24/25) of neuronal MT ends have relatively short flared regions similar to those observed in GMPCPP-stabilized MTs (Fig. 2a), while only one example of a longer curved sheet extension was seen and no highly curved ends associated with in vitro depolymerizing MTs (Fig. 5a) were observed. (c) Three examples of lattice defects observed in neuronal MTs. In each case, a section through the tomogram is depicted on the left and a surface rendering of the MT wall is shown on the right. |