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Figure 2
Structure of bISG15 shown in cartoon rendering. (a) The structure of the loops and helices of bISG15 is shown in blue; β-sheets are shown in gold. The N-terminus is denoted with a green background. The C-terminus is denoted with a purple background. (b) Electrostatic surfaces of bISG15, mISG15 and hISG15 generated using the PDB2PQR server and the surface generated using the Adaptive Poisson–Boltzmann Solver (APBS). Sequence identities for positions 126, 138 and 140 were obtained from the comparison of 92 diverse species of ISG15 and are denoted in parentheses. Arrows indicate the location of Phe40/41 buried within the interface. (c) The C-terminal and N-terminal domains of bISG15, hISG15 and mISG15 superimposed using the least-squares fit of residues on each respective domain.

Journal logoSTRUCTURAL
ISSN: 2059-7983
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