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![[Figure 3]](jc5018fig3mag.jpg)
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Figure 3
The C-terminus of monomer A binds into the active site of the symmetry-related monomer A. (a) Neighbouring residues in the active site of symmetry-related monomer A of HsOGAE602AE605A, with the C-terminal residues bound and the maximum-likelihood/σA-weighted 2Fobs − Fcalc map shown in red contoured at 0.17 e Å−3. (b) Surface representation of the active site with the C-terminus bound in a negatively charged pocket. (c) Overlay of Lys713/A from HsOGAE602AE605A and Tyr715/B from HsOGA11–396+535–715 (in gold) in the binding pocket. (d) Overlay of the C-terminus of chain A of HsOGAE602AE605A and that of HsOGA in complex with glycosylated p53 peptide (PDB entry 5un8), showing Ser149/E in coral. O-GlcNAc is shown in yellow. (e) Overlay of Lys713/A from HsOGAE602AE605A with HsOGA in complex with glycosylated α-crystallin B (PDB entry 5vvv), showing Ser41/B in purple. |
![[Figure 3]](jc5018fig3.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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