Figure 3
Dimer-interaction interfaces of AGEs as a function of buried area. The AGE monomers are represented as a surface and are coloured grey. Residues involved in dimer interactions, as calculated by PISA, are coloured purple (less than 30% buried), pink (less than 60% buried) and red (over 60% buried). The residues at each side of the missing loop are indicated by arrows and labelled. (a) AnaAGE. Top, front; bottom, back. (b) nAGE10 (front). (c) pAGE. Top, front; bottom, back. (d, e) Sequence alignment showing the interface residues using the same colour scheme as used for the surface representations. (d) Front. Residues which are unresolved in the crystal structures are shown in italics. (e) Back. |