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![[Figure 6]](jc5019fig6mag.jpg)
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Figure 6
Sequence conservation amongst AGEs. The sequences (with accession numbers in parentheses) are from Sus scrofa (NP_999065.1), Rattus norvegicus (NP_112357.1), Homo sapiens (NP_002901.2), P. heparinus DSM2366 (ACU05446.1), B. ovatus ATCC 8483 (EDO12673.1), Synechocystis sp. PCC 6803 (BAA18210.1), Nostoc sp. PCC 7120 (WP_010997838.1), Anabaena sp. CH1 (ABG57043.1), A. variabilis ATCC 29413 (WP_011320279.1), N. punctiforme PCC 73101 (WP_012409471.1) and Nostoc sp. KVJ10 (NNBT01000060.1). Identical residues are shown in white on a red background and similar residues in red. α-Helices and β-strands correspond to those in the structures of the AGEs from pig (top; PDB entry 1fp3) and Nostoc sp. KVJ10 (bottom). Red circles (top) indicate residues that participate in catalysis in the AGEs from P. heparinus DSM 2366 and Anabaena sp. CH1 (Lee, Wu et al., 2007  ; Wang et al., 2016). Green circles (bottom) indicate residues that coordinate the chloride ion in Nostoc sp. KVJ10. The blue frames indicate the putative ATP-binding sites (Liao et al., 2012; Wang et al., 2016). |
![[Figure 6]](jc5019fig6.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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