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![[Figure 3]](cb5118fig3mag.jpg)
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Figure 3
Lactose and lactulose binding in BgaR. The image on the left shows a superposition of the monomers of the lactose-bound and lactulose-bound BgaR structures, showing that the saccharides bind in the same pocket in a very similar way; the lactulose-bound structure is shown in cyan and the lactose-bound structure is in wheat. The image on the right is an enlarged perspective with distances shown as black arrows/type for the lactulose-bound structure and in magenta for the lactose-bound structure. A slight shift in the galactose moiety towards the viewer is seen in the lactulose-bound structure. Slight rearrangements in the glucose/fructose ring cause a galactose hydroxyl to move into close proximity to the aromatic C atoms of Tyr31, cause another hydroxyl to make a weaker hydrogen bond to Glu19 and reduce the stacking interactions of the saccharide between Trp5 and Tyr33. |
![[Figure 3]](cb5118fig3.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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