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![[Figure 7]](jb5009fig7mag.jpg)
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Figure 7
Orf11 is predicted to have a GyH domain and a CHAP domain, connected via a linker containing three α-helices. This predicted domain architecture of Orf11 is similar to that of the endolysin protein PlyCA from Streptococcus phage C1. The PlyCA domain architecture was defined using the crystal structure of the protein (PDB entry 4f88; McGowan et al., 2012  ). The domain architecture of Orf11 was assigned using multiple bioinformatics tools. The GyH domain was identified using the FFAS-3D homology-detection server (Xu et al., 2014). The CHAP domain was determined using the Pfam protein-domain database (Finn et al., 2016). The α-helical content within the linker region was defined using the JPred4 secondary-structure prediction server (Drozdetskiy et al., 2015). The residue numbers for the domain boundaries are annotated above the diagrams. |
![[Figure 7]](jb5009fig7.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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