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Figure 4
Interface of LAT1 and the CD98hc ectodomain. (a) Residues proposed to be involved in electrostatic interactions between the two subunits on the extracellular side. CD98hc is shown in green and LAT1 is in cyan (PDB entry 6irt). The EM density map on which the model is based is shown as a mesh (EMD-9722). (b) Side-chain conformations of these putatively interacting residues from the substrate-bound and inhibitor-incubated strutures of LAT1–CD98hc (PDB entries 6irt and 6irs, respectively). (c) Surface of the extracellular interface of substrate-bound LAT1–CD98hc, highlighting the solvent-accessibility of the interface. Putative interacting residues are showns as sticks.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 75| Part 7| July 2019| Pages 660-669
https://doi.org/10.1107/S2059798319009094
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