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Figure 5
Docking of LAT1 in the outward open conformation into a 12 Å resolution EM map. Side (a), front (b) and top (c) views of the docked EM map, represented as a mesh with the CD98hc ectodomain crystal structure shown in blue and a homology model of LAT1 in pink, are shown. Asterisks mark the positions of Gly109 in CD98hc and Cys164 in LAT1. (d) The interdomain linker, Gly109–Gly127, of CD98hc modelled to show the plausibility of inter-subunit disulfide-bond formation between Cys164 of LAT1 and Cys109 of CD98hc (shown as sticks with S atoms in yellow) docked into the EM map (shown as a mesh).

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 75| Part 7| July 2019| Pages 660-669
https://doi.org/10.1107/S2059798319009094
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