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![[Figure 3]](cb5120fig3mag.jpg)
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Figure 3
Relationship of structures with bound AMP. (a) The human and mouse (PDB entry 4gtw) structures of ENPP1 bound to AMP. hENPP1 has grey C atoms and mENPP1 has yellow C atoms for both the AMP molecules and the surrounding residues highlighted in stick representation (Asn277, Leu290, Lys295 and Trp340). The two Zn atoms are shown as grey spheres and the active-site residues are also highlighted in stick representation (three of these, Asp376, His380 and His535, are labelled). (b) hENPP1 with AMP superposed with the hydrolysed product of ADU-S100, with hENPP1 with AMP using the same colour scheme as in (a) and ADU-S100 coloured burnt orange. (c) hENPP1 with AMP superposed with hENPP1 with QPS2 (purple C atoms). (d) hENPP1 with AMP superposed hENPP1 with Ex54 (green C atoms). This figure was generated using PyMOL and GIMP. |
![[Figure 3]](cb5120fig3.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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