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![[Figure 6]](gm5084fig6mag.jpg)
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Figure 6
Crystal structure of BpsDsbA with bound bromophenoxy propanamide (fragment 1). On the left, the protein organization in the crystal structure with PDB code 7luh is represented, with the ligand-binding pocket located at a crystal contact (the two protein monomers are coloured cyan and yellow). The ligand is shown in orange and the binding site is highlighted with a red circle. On the right, a close-up view of the ligand-binding pocket in PDB entry 7luh compared with the oxidized apo structure PDB entry 4k2d (Ireland et al., 2014  ) is depicted. In the absence of fragment 1, the hydrophobic pocket is occupied by the side chain of Tyr110. The residues lining the pocket on the symmetry-related copy of the protein are Val12, Ala13 and Lys15 (yellow). Proteins are shown as a combination of surface, cartoon and stick representations. |
![[Figure 6]](gm5084fig6.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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