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Figure 2
Structure of holo HsADA1. (a) Overlay of holo HsADA1 monomers in the crystal asymmetric unit. Monomer A (magenta) and monomer B (light pink) exhibit only minor structural differences, with an overall r.m.s.d. of 0.34 Å. The green circle indicates the structural gate formed by residues Leu58–Phe65 and Leu182–Asp185. (b) Enlarged view of the zinc-binding regions of monomers A and B. The side chains of the active-site residues are shown as sticks along with the coordinating water molecules. Dashed lines represent coordinating interactions with zinc.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 78| Part 1| January 2022| Pages 91-103
https://doi.org/10.1107/S2059798321011785
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