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Figure 4
Crystal contact analysis. (a) Overlay of four key illustrative structures in the region of the structural gate helix comprising residues 58–65. In all four structures Tyr67 participates in crystal contacts and is in a similar position. (b) Crystal contacts for holo HsADA1 showing polar contacts with the Pro354 and Pro355 main-chain carbonyls. (c) Crystal contacts for holo MmADA showing a water-mediated contact with Glu345. (d) Crystal contacts for holo BtADA showing interaction between Tyr67 and Lys206 as well as between Asp61 and Ser207. (e) Crystal contacts in the closed-conformation structure of BtADA showing contact only between Tyr67 and the main-chain atoms of Val205 and Gly208. Dashed lines represent contacts between 2.6 and 3.5 Å.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 78| Part 1| January 2022| Pages 91-103
https://doi.org/10.1107/S2059798321011785
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