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Figure 5
Cavity and receptor-binding site analysis. (a) Left panel, overview of holo HsADA1 with solvent cavities shown in pale yellow. Right panel, enlargement of the structural gate. (b) Two orientations of the structural gate overlaid with PDB entry 1add in which 1-deaza-adenosine is bound to MmADA, showing good agreement with the cavity in HsADA1. (c) Surface representation of the expected CD26 and adenosine receptor binding sites of HsADA1.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 78| Part 1| January 2022| Pages 91-103
https://doi.org/10.1107/S2059798321011785
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