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Figure 6
Comparison of HsADA1 with HsADA2. (a) Superposition of monomer A (magenta) of HsADA1 and holo HsADA2 (light green; PDB entry 3lgd), with arrows indicating the location of the β2–α2 loop. Inset, enlarged view of the β2–α2 loop showing interaction of β2–α2 with the helix of the structural gate in HsADA1 but not in HsADA2. (b) Enlarged view of the Zn2+ coordination environment. (c) Enlarged view of the structural gate showing that nonligated HsADA2 and CF-bound HsADA2 (gray; PDB entry 3lgg) adopt the same conformation, which is analogous to the open conformation of BtADA (see Fig. 3[link]e).

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 78| Part 1| January 2022| Pages 91-103
https://doi.org/10.1107/S2059798321011785
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