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![[Figure 2]](nz5004fig2mag.jpg)
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Figure 2
Retinal-binding pocket. Conformations of retinal (coloured in light and dark pink) in (a) the DA state (PDB entry 6s63) and (b) the LA state (PDB entry 6guz) of AR3. The blue mesh in (a) and (b) around retinal and Lys226 represents the 2Fobs − Fcalc electron-density map contoured at 1.5σ. Omit maps are shown in Supplementary Fig. S3. (c) Overlay of composite omit maps (2Fobs − Fcalc) of the DA (PDB entry 6s63; grey) and LA (PDB entry 6guz; white) states for retinal and selected amino acids from the surrounding binding pocket. The electron-density maps (LA, blue mesh; DA, green mesh) for the two structures were created using Phenix and are contoured at 1.0σ. The differences in the distributions of electron density surrounding the β-ionone ring and the C13=C14 bond are indicated by yellow arrows. Water molecules are represented by grey and white spheres. All images were created using PyMOL. |
![[Figure 2]](nz5004fig2.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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