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![[Figure 1]](jv5010fig1mag.jpg)
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Figure 1
Autocatalytic maturation and key residues of EcAIII. (a) In the autocatalytic maturation the inactive precursor of EcAIII (PDB entry 2zak; chain A, green; chain B, pink) is cleaved into α/β subunits (PDB entry 2zal; α subunits, green/pink; β subunits, cyan/yellow). PDB entry 2zak carries the T179A mutation. In this process, the nucleophilic Thr179 (marked by a red circle) is liberated, while the linker (red dashed line) is partly degraded. (b) Residues subjected to random mutagenesis, Gly206, Arg207, Asp210 and Ser211, are marked in cyan frames and shown in space-filling representation. The Na+ ion coordinated in the stabilization loop is shown as a purple sphere. |
![[Figure 1]](jv5010fig1.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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