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![[Figure 9]](jv5010fig9mag.jpg)
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Figure 9
Structures of the enzyme in the ON/OFF states. (a) Superposition of WT EcAIII in the ON state, ready to coordinate a substrate molecule (gray, PDB entry 2zal), and mutant RDM1-38 (green) in the OFF state, indicated by rotation of Glu234. (b) The second subunit β of the RDM1-38 structure with Glu234 in two alternative orientations typical of the ON/OFF states; Glu234 in the ON state is locked by hydrogen bonds to His119 and Cys207. (c) Superposition of mutant RDM1-38 (green) in the OFF state and the structures of PvAIII(K) in the ON (orange, PDB entry 4pu6) and OFF (violet, PDB entry 4pv3) states. In all panels, the mutation sites are marked in frames and hydrogen bonds are marked as dashed lines. |
![[Figure 9]](jv5010fig9.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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