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![[Figure 4]](lp5062fig4mag.jpg)
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Figure 4
Comparison of the crystal structures of the individual lobes with full-length RBP. (a) Cartoon representation of the structural alignment of the two chains in the asymmetric unit of RBP-CPC, with the edges of the unresolved region of chains A (Asp95–Met116) and B (Ala98–Met116) shown as spheres. (b) Cartoon representation of the crystallographic dimer of RBP-CPN. (c, d) Superposition of the cartoon structures of full-length RBP with RBP-CPC (c) and RBP-CPN (d), respectively. R.m.s.d. values over all Cα atoms of chain A of each structure are provided next to each figure. (e) Missing density in the RBP-CPC map spanning residues Asp96–Met116. The crystal structure is shown as sticks, where chain A is colored yellow and symmetry mates are colored gray. A stick representation of the corresponding Rosetta model (residues Ile92–Gly125) is shown as an overlay in cyan. Water molecules are depicted as red spheres. A 2Fo − Fc map contoured at an r.m.s.d. of 1.0 is shown as gray mesh. The representation and alignment were obtained using PyMOL 2.3.0 (Schrödinger) and the align command with cycles=0. |
![[Figure 4]](lp5062fig4.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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