Slice'N'Dice: maximizing the value of predicted models for structural biologists

Simpkin, A.J.; Elliot, L.G.; Joseph, A.P.; Burnley, T.; Stevenson, K.; Sánchez Rodríguez, F.; Fando, M.; Krissinel, E.; McNicholas, S.; Rigden, D.J.; Keegan, R.M.

doi:10.1107/S2059798325001251

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 3
Flowchart showing (a) the Slice'N'Dice hybrid MR mode, where Phaser jobs are ordered by slice size and run in order if a single processor is specified or run in parallel if multiple processors are specified. Any solutions found in this initial Phaser step are combined and used as a fixed model that is input into the MOLREP subprocess [detailed in (c)]. (b) The Slice'N'Dice EM pipeline. (c) The MOLREP PTF step where we attempt to place additional slices from a fixed input model. If the R scores improve the output is either set as a fixed model for subsequent slices or returned as our final MR solution.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 81| Part 3| March 2025|

https://doi.org/10.1107/S2059798325001251

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