Enhanced intensity-based clustering of isomorphous multi-crystal data sets in the presence of subtle variations

Thompson, A.J.; Beilsten-Edmands, J.; Tam, C.; Sanchez-Weatherby, J.; Sandy, J.; Mikolajek, H.; Axford, D.; Jaho, S.; Hough, M.A.; Winter, G.

doi:10.1107/S2059798325004589

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 5
Comparison of HCA analysis of bovine, porcine and human insulin using xia2.multiplex with and without CC σ-weighting as described in Section 2.1

. Data sets corresponding to bovine insulin are highlighted in orange, data sets corresponding to porcine insulin are highlighted in pink and data sets corresponding to human insulin are highlighted in blue. Dendrogram links have colours that are randomly allocated and not representative of groups. The top dendrograms for the unweighted heatmaps show only the lower part of the dendrogram to improve visualization, whereas the full dendrograms are shown to the left.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 81| Part 6| June 2025| Pages 278-290

https://doi.org/10.1107/S2059798325004589

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