Structural dynamics of IDR interactions in human SFPQ and implications for liquid–liquid phase separation

Koning, H.J.; Lai, V.; Sethi, A.; Chakraborty, S.; Ang, C.-S.; Fox, A.H.; Duff, A.P.; Whitten, A.E.; Marshall, A.C.; Bond, C.S.

doi:10.1107/S2059798325005303

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 7
Comparative amino-acid enrichment profiles of the human DBHS paralogs across N-terminal and C-terminal IDRs and the DBHS domain. (a) Amino-acid enrichment and depletion histogram of the N- and C-terminal IDRs and the DBHS domain of SFPQ. DBHS sequences are mapped against the average enrichment and depletion of amino acids in the human proteome. (b) Amino-acid frequency analysis of the N- and C-terminal IDRs and the DBHS domain of SFPQ using a sliding window of 30 amino acids. (c) Amino-acid enrichment and depletion histogram of the N-terminal and C-terminal IDRs and the DBHS domain of NONO mapped against the average enrichment and depletion of the human proteome. (d) Amino-acid frequency analysis of the N-terminal and C-terminal IDRs and the DBHS domain of NONO using a sliding window of 30 amino acids. (e) Amino-acid enrichment and depletion histogram of the N-terminal and C-terminal IDRs and the DBHS domain of PSPC1 mapped against the average enrichment and depletion of the human proteome. (f) Amino-acid frequency analysis of the N-terminal and C-terminal IDRs and the DBHS domain of PSPC1 using a sliding window of 30 amino acids.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 81| Part 7| July 2025| Pages 357-379

https://doi.org/10.1107/S2059798325005303

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