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![[Figure 5]](chr5006fig5mag.jpg)
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Figure 5
Displacement of Cα atoms (ΔCα) in HbHNL (PDB entry 1yb6), HNL40 (PDB entry 8sni) and HNL71 (PDB entry 9clr) relative to wild-type SABP2. While the structures of SABP2 and HbHNL differ significantly, the addition of 40 changes to HbHNL to create HNL40 makes the region near the active site more similar to SABP2 and the 71 changes in HNL71 make this region identical to SABP2. All three images show the structure of SABP2 (PDB entry 1y7i), but the color and cartoon thickness indicate the displacement of the Cα atoms in the other structures. The triad and bound salicylic acid are shown as pink sticks. The representations are scaled so that a red, thick sausage indicates a displacement of ∼3 Å in all three structures, with the exception of residues 136–141 (circled) in the lid region of SABP2. The Cα positions in this region differ by up to 11 Å from those in HbHNL, so this representation was scaled down for clarity. The dotted line near the top in the HbHNL comparison indicates the two-amino-acid insertion in SABP2 that has no counterpart in HbHNL. The two dotted-line regions in the HNL71 comparison (marked by red ovals) were not observed in the X-ray structure, suggesting disorder. The HNL40 comparison shows the Cα atoms as spheres at the locations of the 40 changes. The HNL71 comparison shows its additional 31 substitutions as spheres at the Cα positions. |
![[Figure 5]](chr5006fig5.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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