Crystal structure of the β₂-microglobulin–BBM.1 antibody complex reveals the molecular basis of antigen recognition

This study presents the crystal structure of human β₂-microglobulin (β₂M) complexed with the monoclonal antibody BBM.1, revealing critical interactions involving key epitope residues. These structural insights validate prior biochemical findings and provide a foundational basis for the development of precise therapeutic approaches targeting β₂M in various diseases.

XFBLD-Platform: a crystallographic fragment-screening platform at Shanghai Synchrotron Radiation Facility

A crystallographic fragment-screening platform, referred to as the XFBLD-Platform, developed at Shanghai Synchrotron Radiation Facility accelerates fragment-based lead discovery through an integrated high-throughput workflow for structure-based drug development.

Understanding domain swapping in the c-Src SH3 domain through hinge-loop mutagenesis

The role of the hinge loop and the open interface in the 3D domain swapping of the c-Src SH3 domain is reported.

Crystal structures of 40- and 71-substitution variants of hydroxynitrile lyase from rubber tree

Variants HNL16, HNL40 and HNL71 of hydroxynitrile lyase from Hevea brasiliensis contain 16, 40 and 71 mutations, respectively, to make increasingly larger regions surrounding the active site identical in sequence to the esterase SABP2. X-ray structures of HNL40 and HNL71 reveal changes to the oxyanion hole and a new tunnel, which may contribute to their efficient esterase activity.

Rengachary Parthasarathy (1939–2025): a life journey from Nagari to San Jose

Rengachary Parthasarathy is remembered.