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![[Figure 6]](chr5006fig6mag.jpg)
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Figure 6
Substitutions in HNL40 and HNL71 create an SABP2-like tunnel (yellow) that is missing in HbHNL. HbHNL (far left) contains two tunnels (blue) that lead from the active site to the left. The catalytic triad is shown as sticks with orange C atoms. In contrast, SABP2 (far right) contains seven tunnels; six of these tunnels (blue) lead from the active site to the left, while one tunnel (yellow) leads from the active site to the right. HNL40 and HNL71 each contain four tunnels; three of these tunnels (blue) lead from the active site to the left, while one tunnel (yellow, near the insertion site) leads from the active site to the right. The 39 substitutions in HNL40 are colored orange, while the two insertions are colored pink. The additional 31 changes in HNL71 are shown in yellow. Tunnels were identified using Caver Web (Stourac et al., 2019  ) with default settings. |
![[Figure 6]](chr5006fig6.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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