Understanding domain swapping in the c-Src SH3 domain through hinge-loop mutagenesis

Salinas-Garcia, M.C.; Plaza-Garrido, M.; Martinez, J.C.; Camara-Artigas, A.

doi:10.1107/S2059798325006977

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 5
Cartoon representation of the topology of the intertwined dimers of (a) Src_Abl-2 (PDB entry 7pvw), (b) Src_Abl-RT (PDB entry 7pvz) and (c) the WT c-Src SH3 domain (PDB entry 6xvo). Residues involved in new interactions in the open interface are shown as sticks. The new 3₁₀-helix in the open interface of Src_Abl-2 is marked with a red arrow. The composite omit map of the residues belonging to the hinge loop in each intertwined dimer is also shown.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 81| Part 9| September 2025| Pages 492-510

https://doi.org/10.1107/S2059798325006977

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