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Figure 8
Multiple sequence alignment occupancy histogram distributions for AlphaFold2 human proteome predictions, as annotated in MobiDB. The three non-predictive modes (barbed wire, pseudostructure and unphysical) show similar distributions to each other. Near-predictive has a distribution more similar to the high-pLDDT modes, supporting our association of near-predictive regions with predictive. Similarity between near-predictive and unpacked high-pLDDT suggests that near-predictive also contains conditionally binding regions. |
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