Optimal 1TEL–target protein linker character is target protein-dependent

Pedroza Romo, M.J.; Keliiliki, A.; Averett, J.C.; Gonzalez, J.F.; Noakes, E.; Wilson, E.W.; Smith, C.; Averett, B.; Hansen, D.; Nickles, R.; Bradford, M.; Soleimani, S.; Smith, T.; Nawarathnage, S.; Samarwickrama, P.; Kelsch, A.; Bunn, D.; Stewart, C.; Abiodun, W.; Tsubaki, E.; Brown, S.; Doukov, T.I.; Moody, J.D.

doi:10.1107/S2059798326002494

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

IUCr IT WDC

home archive editors for authors for readers submit subscribe open access

view article

Figure 6
Structure and lattice interactions of a 1TEL-PA-DARPin crystal. (a) Structure of the 1TEL-PA-DARPin monomer (PDB entry 9db5), with 1TEL shown in pale green and the DARPin in bright green. (b) The unit cell of 1TEL-PA-DARPin in space group P6₅ is outlined in black, with symmetry mates displayed in the same colouring as in (a). (c) Crystal lattice representation with 1TEL polymers shown as ribbons and symmetry mates displayed in grey. 1TEL regions are in light grey, DARPin regions are in dark grey and the monomer is coloured as in (a). (d)–(g) Close-up views of the interactions between the DARPin (bright green) and adjacent DARPin proteins from neighbouring polymers or neighbouring 1TEL units (light grey). Proteins are depicted in cartoon representation, with interacting residues shown as sticks and spheres and hydrogen bonds shown as yellow dotted lines. Figures were prepared using PyMOL (Schrödinger) and Microsoft PowerPoint.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 82| Part 5| May 2026| Pages 516-532

https://doi.org/10.1107/S2059798326002494

Open

access

Follow Acta Cryst. D

Search IUCr Journals		doi		Advanced search
Author		volume	page