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![[Figure 1]](ai5017fig1mag.jpg)
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Figure 1
Structure-based design of a cyclic GSDMD peptide to inhibit cleavage and pore formation. (a) Using available co-crystal structures of caspase-1 and GSDMD (Wang et al., 2020  ; Liu et al., 2020), we postulated that a cyclic peptide could bind at the caspase-1 βIII dimer binding site highlighted by the green dashed box. (b) The two caspase-1 βIII peptide-binding segments with side chains rendered as sticks. (c) Using structure-based design and computation, a set of single cyclic peptides were designed. Residues in bold were modified based on structure-based design and computational residue scanning. |
![[Figure 1]](ai5017fig1.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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