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![[Figure 5]](ai5017fig5mag.jpg)
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Figure 5
Structure comparison of hGSDMD-CTD–Peptide 2 with hGSDMD-CTD–caspase-1. (a) Superposition of the hGSDMD-CTD–Peptide 2 exosite (hGSDMD in pink and Peptide 2 in yellow and cyan) onto the hGSDMD-CTD–caspase-1(P20/P10) complex structure (PDB entry 6kn0) in green. The hydrogen bonds are colored yellow for peptide and green for caspase-1. (b) Partial sequence alignment of caspase-1, caspase-4 and caspase-11 involved in forming β-sheets and the Peptide 2 sequence. (c) Superposition of the hGSDMD-CTD interface of Peptide 2 onto P20/P10 with the same color scheme as in (a) |
![[Figure 5]](ai5017fig5.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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