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![[Figure 1]](cb5156fig1mag.jpg)
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Figure 1
Structure of the nucleosome (PDB entry 1aoi). (a) Overview of the nucleosome (disk view). H3 is colored blue, H4 green, H2A yellow, H2B red and DNA gray. (b) Superhelical locations (SHLs) are defined as the points where the major groove faces inwards, towards the histone octamer. The base pair at the center of the histone-octamer footprint on the DNA is called the dyad and is numbered bp 0/SHL 0 by convention. Each gyre has seven SHLs, numbered positively on the front gyre and negatively on the back gyre (SHLs with the same numbers but opposite signs refer to equivalent locations related by the pseudo-twofold symmetry of the dyad axis, and a fractional SHL such as 1.5 refers to the minor groove between two SHLs, in this example between SHLs 1 and 2). Only the front gyre is displayed here for clarity. (c) Electrostatic potential of the histone octamer. The H2A–H2B acidic patch is labeled. |
![[Figure 1]](cb5156fig1.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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