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![[Figure 2]](cb5156fig2mag.jpg)
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Figure 2
Current structural knowledge about human ALC1. (a) Domain structure of ALC1. (b) AlphaFold2 prediction of full-length ALC1. Left, colored by domain as in (a), with domains labeled. Right, colored by pLDDT (prediction confidence). Residues of the regulatory linker segment (RLS) are displayed as sticks. From AlphaFold-DB AF-Q86WJ1-F1-v3. (c) Crystal structure of ALC1 in its auto-inhibited state, colored by domain as in (a), with the antibody used for crystallization shown as a translucent cyan surface. From PDB entry 7epu. (d) Cryo-EM structure of the RLS of ALC1 cross-linked to a nucleosome (disk view). From PDB entry 6zhx. (e) Cryo-EM structure of ALC1 R857Q cross-linked to an unmodified nucleosome (gyres view). From PDB entry 7enn. (f) Cryo-EM structure of ALC1 bound to a nucleosome site-specifically tri-ADP-ribosylated on H2B-Ser6 (gyres view). From PDB entry 8b0a. In (d), (e) and (f), ALC1 is colored by domain as in (a) and the nucleosome is colored as in Fig. 1 ![[link]](../../../../../../logos/arrows/d_arr.gif){kind=small} (a) and shown as a translucent surface for clarity. |
![[Figure 2]](cb5156fig2.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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