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![[Figure 5]](raj5002fig5mag.jpg)
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Figure 5
Structural biology impact across selected MSD therapeutic targets. Surface and ribbon representations of molecular targets from selected MSD products whose discovery or optimization was informed by structural biology. Distinct subunits or functional domains are colored to highlight relative positions, interfaces and ligand-binding sites. (a) β-Lactamase shown as ribbons (teal) in complex with imipenem (orange; PDB entry 1bt5; Maveyraud et al., 1998  ). (b) HIV aspartyl protease shown as ribbons (teal and white) with indinavir (Crixivan, orange) depicted in stick representation (PDB entry 1hsh; Chen et al., 1994). (c) HIV reverse transcriptase (PDB entry 3drp; Tucker et al., 2008). (d) HIV integrase (PDB entry 3l2v; Hare et al., 2010). (e) Dipeptidyl peptidase-4 (DPP-4; PDB entry 2p8s; Biftu et al., 2007). (f) Human papillomavirus (HPV) capsid protein fragment (PDB entry 3j6r; Cardone et al., 2014). (g) Pembrolizumab in complex with PD-1 (PDB entry 5dk3; Scapin et al., 2015). (h) Hepatitis C virus (HCV) protein target (PDB entry 3sud; Romano et al., 2012). (i) SARS-CoV-2 RNA-dependent RNA polymerase (PDB entry 7ozu; Kabinger et al., 2021). (j) Orexin receptor (active state; PDB entry 7l1u; Hong et al., 2021). (k) PCSK9 (PDB entry 3h42; Chan et al., 2009). (l) Respiratory syncytial virus (RSV) fusion (F) protein (PDB entry 6ous; Tang et al., 2019). Created in BioRender. Gabelli, S. (2026), https://BioRender.com/hbesh6q. |
![[Figure 5]](raj5002fig5.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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