Structural basis of regioselective double halogenation of the β-carboline tryptoline by the single-component halogenase AetF

Bork, S.; Horstmeier, H.J.; Scharkowski, B.; Niemann, H.H.

doi:10.1107/S2059798326005954

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 1
Conversion of tryptoline catalyzed by AetF. Analytic RP-HPLC chromatograms recorded at 280 nm show the conversion of tryptoline by AetF in the presence of bromide (red) or iodide (blue) after (a) 4 h and (b) overnight reaction. In both the bromination and iodination assays, two distinct products occur, identified by LC-MS as monohalogenated (2a, 2b) and dihalogenated (3a, 3b) derivatives of tryptoline.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 82| Part 7| July 2026| Pages 836-844

https://doi.org/10.1107/S2059798326005954

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